Katie DeAvilla, PGY1

Le Bonheur Children's Hospital, Memphis, Tennessee

Objectives: 

1. Understand the role of ciprofloxacin/dexamethasone ophthalmic drops in tracheostomy patients
2. Evaluate the safety and efficacy of ciprofloxacin/dexamethasone ophthalmic drops administered intratracheally post tracheal procedures

Abstract:

Introduction: Tracheostomy tubes often become colonized with bacteria and develop biofilms that may be associated with a greater risk of infection and complications. Organisms commonly isolated in tracheal secretions include Pseudomonas aeruginosa, Klebsiella pneumoniae, Streptococcus pneumoniae, and Staphylococcus aureus. These gram negative organisms demonstrate good susceptibility to ciprofloxacin at our institution; therefore, it is a reasonable therapeutic option for prophylaxis in patients who have undergone tracheal procedures. Tracheostomy tubes may also lead to increased local inflammation which may contribute to infectious complications. The use of glucocorticoids has been shown to lower the number of neutrophils and lymphocytes found in tracheal aspirates. This research project will evaluate the safety and efficacy of ciprofloxacin/dexamethasone ophthalmic drops administered intratracheally post tracheal procedures.

Methods: All computerized physician order entries for ciprofloxacin/dexamethasone administered intratracheally from January 1, 2012 to December 31, 2017 will be retrospectively analyzed in this study. Patient demographics will include patient age, gender, race and weight. Additional information to be collected includes: dose, duration of therapy, procedure type, respiratory and blood cultures prior to and during therapy, concomitant antibiotic use, length of stay, and readmission status. The following laboratory parameters will be evaluated prior to, during, and following therapy: white blood cell count, erythrocyte sedimentation rate, and C-reactive protein. Descriptive statistics will be utilized to characterize the data. This study is under review by our Institutional Review Board.

Results: Results will be submitted within final slides.

Conclusion: Conclusion will be submitted within final slides.

Handout Slides:

View Slides